2-Fluoroamphetamine (2-FA) is a stimulant drug from the amphetamine family which has been sold as a designer drug.2-Fluoroamphetamine differs from 3- and 4-fluoroamphetamine in the position of the fluorine atom on the aromatic ring, making them positional isomers of one another. The replacement of a hydrogen atom with a fluorine atom in certain compounds to facilitate passage through the blood-brain barrier, as is desirable in central nervous system pharmaceutical agents, is a common practice due to the corresponding increase in lipophilicity granted by this substitution.
2-FA is part of a series of amphetamine analogs that first appeared on the online research chemical market in the 2010s. These compounds include 2-FMA, 3-FA, 3-FEA, and 4-FA and are reported to produce a range of stimulating and euphoric effects, many of which have been used as research chemical substitutes for classical street stimulants and entactogens. Of these, 2-FA is considered to be most amphetamine-like in its subjective effects. It is commonly compared to the d-isomer of amphetamine (Dexedrine).
2-FA is commonly taken orally. While capable of being taken via insufflation or vaporization, this has been reported to be highly unpleasant and noxious compared to its parent compound. Despite some users reporting efficacy as an alternative to prescription stimulants for ADHD, little is known about the potential toxicological effects that accompany its long-term use as a substitute for prescribed stimulants.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2-FA. It is highly advised to use harm reduction practices if using this substance.